Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.

نویسندگان

  • Beatriz Tavira
  • Eliecer Coto
  • Armando Torres
  • Carmen Díaz-Corte
  • Beatriz Díaz-Molina
  • Francisco Ortega
  • Manuel Arias
  • Juan M Díaz
  • Rafael Selgas
  • Carlos López-Larrea
  • Marta Ruiz-Ortega
  • Alberto Ortiz
  • Elena González
  • Josep M Campistol
  • Victoria Alvarez
چکیده

KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association.

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عنوان ژورنال:
  • Molecular genetics and metabolism

دوره 105 3  شماره 

صفحات  -

تاریخ انتشار 2012